This new paper reports an entire scan of the human genome and 370,000 gene variants from 1000 warfarin patients. In it, they identify the 2 genes that have been implicated in determining the warfarin dose in patients. However, they add CYP4F2 to the mix. Allan Rettie's group at UW (my alma mater) recently published that CYP4F2 is involved in vitamin K metabolism. The effect of mutation in this CYP450 is to increase the amount of vitamin K in this patient population that results in the need for an increase in the dose of warfarin by about 1 mg.
Thursday, March 26, 2009
Three Genes Important for Warfarin Dose
This new paper reports an entire scan of the human genome and 370,000 gene variants from 1000 warfarin patients. In it, they identify the 2 genes that have been implicated in determining the warfarin dose in patients. However, they add CYP4F2 to the mix. Allan Rettie's group at UW (my alma mater) recently published that CYP4F2 is involved in vitamin K metabolism. The effect of mutation in this CYP450 is to increase the amount of vitamin K in this patient population that results in the need for an increase in the dose of warfarin by about 1 mg.
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