This 2009 paper out of Dr. Guengerich's labat Vanderbilt identifies the "natural" function of the drug metabolizing CYP450s present in human liver extracts. They used a combination of 18O/16O isotopic labeling techniques in their in vitro incubations and LC/MS analysis of the extracts to identify a number of fatty acids as as substrates of CYP1A2, 2C8, and 2C9. Very cool idea!
Monday, April 06, 2009
Natural Function of Drug Metabolizing CYP450s
This 2009 paper out of Dr. Guengerich's labat Vanderbilt identifies the "natural" function of the drug metabolizing CYP450s present in human liver extracts. They used a combination of 18O/16O isotopic labeling techniques in their in vitro incubations and LC/MS analysis of the extracts to identify a number of fatty acids as as substrates of CYP1A2, 2C8, and 2C9. Very cool idea!
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