This 2008 paper describes the expression of various drug metabolizing enzymes, tranporters, and transcription factors at the human blood brain barrier. They used a variety of techniques including western blotting and mRNA analysis and are the first group to report the levels of expression at the human BBB. They found that the major CYP450 and transporters expressed at the BBB were CYP1B1 and BRCP and Pgp, respectively. The one caveat to the study is that they isolated their BBB's from patients that had some form of epilepsy.
Sunday, February 22, 2009
DME Expression at the BBB
This 2008 paper describes the expression of various drug metabolizing enzymes, tranporters, and transcription factors at the human blood brain barrier. They used a variety of techniques including western blotting and mRNA analysis and are the first group to report the levels of expression at the human BBB. They found that the major CYP450 and transporters expressed at the BBB were CYP1B1 and BRCP and Pgp, respectively. The one caveat to the study is that they isolated their BBB's from patients that had some form of epilepsy.
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