Furanocoumarins have long been implicated in the so-called grapefruit juice effect on drug absorption and metabolism. These compounds are known to inhibit CYP3A4/5 in the intestine and liver and if a drug that metabolized by CYP3A4 is taken along with drinking a glass of grapefruit juice, you might observe an increase in blood levels of the drug. This team in Florida has discovered that an edible mushroom like fungus called Morchella esculenta can removed most of these furanocoumarins from the grapefruit juice and thereby reduce the amount of CYP3A4 inhibition by about 60%. Previous research by the team showed that an inedible mushroom could carry out this process as well. I'm not so sure I want to start mixing in mushrooms with my grapefruit juice (sounds disgusting), but this research could spur on other ideas of how to remove these interfering compounds.
Furanocoumarins have long been implicated in the so-called grapefruit juice effect on drug absorption and metabolism. These compounds are known to inhibit CYP3A4/5 in the intestine and liver and if a drug that metabolized by CYP3A4 is taken along with drinking a glass of grapefruit juice, you might observe an increase in blood levels of the drug. This team in Florida has discovered that an edible mushroom like fungus called Morchella esculenta can removed most of these furanocoumarins from the grapefruit juice and thereby reduce the amount of CYP3A4 inhibition by about 60%. Previous research by the team showed that an inedible mushroom could carry out this process as well. I'm not so sure I want to start mixing in mushrooms with my grapefruit juice (sounds disgusting), but this research could spur on other ideas of how to remove these interfering compounds.
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